Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Maximization of the Minicircle DNA Vaccine Production Expressing SARS-CoV-2 RBD

25 Apr 2022

Abstract excerpt

Nucleic acid vaccines have been proven to be a revolutionary technology to induce an efficient, safe and rapid response against pandemics, like the coronavirus disease (COVID-19). Minicircle DNA (mcDNA) is an innovative vector more stable than messenger RNA and more efficient in cell transfection and transgene expression than conventional plasmid DNA. This work describes the construction of a parental plasmid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to Viral gastroenteritis research and epidemiology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35625727
DOI: 10.3390/biomedicines10050990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Maximization of the Minicircle DNA Vaccine Production Expressing SARS-CoV-2 RBDPMID 35625727Read ↗

Establishment of a Reverse Genetics System for SARS-CoV-2 Using Circular Polymerase Extension ReactionSemantic proximity Read ↗

miniVec: A miniaturized plasmid backbone supporting antibiotic-free and additive-free fermentation with enhanced yield and functionalitySemantic proximity Read ↗

Evaluation of Vibrio natriegens as a fast-growing alternative host for plasmid DNA productionSemantic proximity Read ↗

Prokaryote- and Eukaryote-Based Expression Systems: Advances in Post-Pandemic Viral Antigen Production for VaccinesSemantic proximity Read ↗

Engineering a Reliable and Convenient SARS-CoV-2 Replicon System for Analysis of Viral RNA Synthesis and Screening of Antiviral Inhibitors.Semantic proximity Read ↗

A novel cell culture system modeling the SARS-CoV-2 life cycleSemantic proximity Read ↗

Use of a Bacterial Artificial Chromosome to Generate Recombinant SARS-CoV-2 Expressing Robust Levels of Reporter GenesSemantic proximity Read ↗

An optimized circular polymerase extension reaction-based method for functional analysis of SARS-CoV-2Semantic proximity Read ↗

Reverse genetics systems for SARS‐CoV‐2Semantic proximity Read ↗

A study protocol to prepare an RBD protein for vaccine against COVID-19Semantic proximity Read ↗

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 researchSemantic proximity Read ↗

Modified Escherichia coli B (BL21), a superior producer of plasmid DNA compared with Escherichia coli K (DH5α)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.