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Causal Graph Among Serum Lipids and Glycemic Traits: A Mendelian Randomization Study.

Diabetes - 1 Aug 2022

Zhu Ziwei, Wang Kai, Hao Xingjie, Chen Liangkai, Liu Zhonghua, Wang Chaolong

Abstract excerpt

We systematically investigated the bidirectional causality among HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TGs), fasting insulin (FI), and glycated hemoglobin A1c (HbA1c) based on genome-wide association summary statistics of Europeans (n = 1,320,016 for lipids, 151,013 for FI, and 344,182 for HbA1c). We applied multivariable Mendelian randomization (MR) to account for the correlation among...

Topics

Blood Glucose
Cholesterol, HDL
Cholesterol, LDL
Diabetes Mellitus, Type 2
Genome-Wide Association Study
Glycated Hemoglobin
Humans
Insulin
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Factors

Triglycerides

Source

Identifiers

PMID: 35622003
DOI: 10.2337/db21-0734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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