Article
A potential early clinical phenotype of necrotizing meningoencephalitis in genetically at-risk pug dogs.
Journal of veterinary internal medicine - 1 Jul 2022
Windsor Rebecca, Stewart Samuel, Schmidt Jessica, Mosqueda Mario, Piras Ignazio, Keller Stefan M, Steinmetz Briana, Borjesson Dori L, Huentelman Matthew, Khanna Chand
Abstract excerpt
BACKGROUND: Necrotizing meningoencephalitis (NME) in the pug dogs is a fatal neuroinflammatory disease associated with rapid progression and poor response to conventional immunosuppressive therapy. Diagnosis is typically made after severe neurological abnormalities have manifested. HYPOTHESIS/OBJECTIVE: Pug dogs at genetic risk for NME might manifest neurological abnormalities before developing pathognomonic...
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