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Article

Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel loci.

PLoS genetics - 1 Feb 2017

Evans Jacquelyn M, Noorai Rooksana E, Tsai Kate L, Starr-Moss Alison N, Hill Cody M, Anderson Kendall J, Famula Thomas R, Clark Leigh Anne

Abstract excerpt

Juvenile dermatomyositis (JDM) is a chronic inflammatory myopathy and vasculopathy driven by genetic and environmental influences. Here, we investigated the genetic underpinnings of an analogous, spontaneous disease of dogs also termed dermatomyositis (DMS). As in JDM, we observed a significant association with a haplotype of the major histocompatibility complex (MHC) (DLA-DRB1*002:01/-DQA1*009:01/-DQB1*001:01),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28158183
DOI: 10.1371/journal.pgen.1006604
PMCID: PMC5315411

Genes

PAN2

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