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Article

Lipid metabolism dysfunction induced by age-dependent DNA methylation accelerates aging

24 May 2022

Abstract excerpt

Epigenetic alterations and metabolic dysfunction are two hallmarks of aging. However, the mechanism of how their interaction regulates aging, particularly in mammals, remains largely unknown. Here we show ELOVL fatty acid elongase 2 (Elovl2), a gene whose epigenetic alterations are most highly correlated with age prediction, contributes to aging by regulating lipid metabolism. We applied artificial intelligence...

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PMID: 35610223
DOI: 10.1038/s41392-022-00964-6

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