Article
Biclustering reveals potential knee OA phenotypes in exploratory analyses: Data from the Osteoarthritis Initiative.
PloS one - 1 Jan 2022
Nelson Amanda E, Keefe Thomas H, Schwartz Todd A, Callahan Leigh F, Loeser Richard F, Golightly Yvonne M, Arbeeva Liubov, Marron J S
Abstract excerpt
OBJECTIVE: To apply biclustering, a methodology originally developed for analysis of gene expression data, to simultaneously cluster observations and clinical features to explore candidate phenotypes of knee osteoarthritis (KOA) for the first time. METHODS: Data from the baseline Osteoarthritis Initiative (OAI) visit were cleaned, transformed, and standardized as indicated (leaving 6461 knees with 86 features)....
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