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Bat Red Blood Cells Express Nucleic Acid–Sensing Receptors and Bind RNA and DNA

1 May 2022

Abstract excerpt

RBCs demonstrate immunomodulatory capabilities through the expression of nucleic acid sensors. However, little is known about bat RBCs, and no studies have examined the immune function of bat erythrocytes. In this study, we show that bat RBCs express the nucleic acid-sensing TLRs TLR7 and TLR9 and bind the nucleic acid ligands, ssRNA, and CpG DNA. Collectively, these data suggest that, like human RBCs, bat...

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PMID: 35595326
DOI: 10.4049/immunohorizons.2200013

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