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Cutting Edge: Antibody-Mediated TLR7-Dependent Recognition of Viral RNA

1 Mar 2007

Abstract excerpt

TLR7 recognizes the genome of ssRNA viruses such as Coxsackievirus B. Because TLR7 is expressed in intracellular compartments, viral RNA must be internalized before its recognition by TLR7. In this study, we define plasmacytoid dendritic cells (pDC) as peripheral blood mononuclear immune cells that respond to Coxsackievirus. pDC activation by Coxsackievirus B requires the presence of specific antiviral Abs. We...

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PMID: 17339429
DOI: 10.4049/jimmunol.178.6.3363

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