Characterization of ovine TLR7 and TLR8 protein coding regions, detection of mutations and Maedi Visna virus infection.

doi:10.1016/j.vetimm.2010.06.015

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Article

Characterization of ovine TLR7 and TLR8 protein coding regions, detection of mutations and Maedi Visna virus infection.

Veterinary immunology and immunopathology - 15 Nov 2010

Mikula Ivan, Bhide Mangesh, Pastorekova Silvia, Mikula Ivan

Abstract excerpt

Toll-like receptors (TLRs) 2, 3, 4, 7, 8 and 9 play a crucial role in the recognition of viral entities and modulation of the innate immune system. This work presents sequence analysis of ovine TLR7 and TLR8 genes, depicts novel mutations and describes frequencies of mutations in Maedi Visna infected and healthy sheep. Totally 48 samples of the breed Tsigai were analyzed for the presence of mutations. Within 20...

Topics

Amino Acid Sequence
Amino Acid Substitution
Animals
Base Sequence
Cattle
DNA Mutational Analysis
DNA Primers
Female
Genetic Predisposition to Disease
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Mutation, Missense

Pneumonia, Progressive Interstitial, of Sheep

Point Mutation

Protein Structure, Secondary

Repetitive Sequences, Amino Acid

Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 20638136
DOI: 10.1016/j.vetimm.2010.06.015

Genes

TLR7
TLR8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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