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Article

Association between psychiatric hospitalizations of patients with schizophrenia and polygenic risk scores based on genes with altered expression by antipsychotics.

Acta psychiatrica Scandinavica - 1 Aug 2022

Facal Fernando, Arrojo Manuel, Paz Eduardo, Páramo Mario, Costas Javier

Abstract excerpt

OBJECTIVE: To test whether a schizophrenia polygenic risk score (PRS) based on the subset of polymorphisms that affect brain expression of genes with altered expression by antipsychotics (exprAP PRS) is associated with psychiatric readmission of patients with schizophrenia. METHODS: The study involved 427 patients with schizophrenia. Genes with altered expression by antipsychotics were extracted from the...

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PMID: 35582973
DOI: 10.1111/acps.13444

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