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Article

Using potential variable to study gene-gene and gene-environment interaction effects with genetic model uncertainty.

Annals of human genetics - 1 Sept 2022

Hu Xiaonan, Meng Zhen

Abstract excerpt

One of the critical issues in genetic association studies is to evaluate the risk of a disease associated with gene-gene or gene-environment interactions. The commonly employed procedures are derived by assigning a particular set of scores to genotypes. However, the underlying genetic models of inheritance are rarely known in practice. Misspecifying a genetic model may result in power loss. By using some...

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PMID: 35582845
DOI: 10.1111/ahg.12470

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