Article
Etonogestrel Administration Reduces the Expression of PHOX2B and Its Target Genes in the Solitary Tract Nucleus.
International journal of molecular sciences - 27 Apr 2022
Cardani Silvia, Janes Tara A, Saini Jasmeen K, Di Lascio Simona, Benfante Roberta, Fornasari Diego, Pagliardini Silvia
Abstract excerpt
Heterozygous mutations of the transcription factor PHOX2B are responsible for Congenital Central Hypoventilation Syndrome, a neurological disorder characterized by inadequate respiratory response to hypercapnia and life-threatening hypoventilation during sleep. Although no cure is currently available, it was suggested that a potent progestin drug provides partial recovery of chemoreflex response. Previous in...
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