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PD-L1 Expression in Non-Small Cell Lung Cancer Specimens: Association with Clinicopathological Factors and Molecular Alterations.

International journal of molecular sciences - 19 Apr 2022

Mansour Mohammed S I, Malmros Karina, Mager Ulrich, Ericson Lindquist Kajsa, Hejny Kim, Holmgren Benjamin, Seidal Tomas, Dejmek Annika, Dobra Katalin, Planck Maria, Brunnström Hans

Abstract excerpt

Immune checkpoint inhibitors (ICI) targeting programmed cell death-1 or its ligand (PD-L1) have improved outcomes in non-small cell lung cancer (NSCLC). High tumor PD-L1 expression, detected by immunohistochemistry (IHC) typically on formalin-fixed paraffin-embedded (FFPE) histological specimens, is linked to better response. Following our previous investigation on PD-L1 in cytological samples, the aim of this...

Topics

Adenocarcinoma
B7-H1 Antigen
Carcinoma, Non-Small-Cell Lung
ErbB Receptors
Humans
Ligands
Lung Neoplasms
Mutation
Proto-Oncogene Proteins p21(ras)
Retrospective Studies

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PMID: 35562908
DOI: 10.3390/ijms23094517
PMCID: PMC9101150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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