Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes.

doi:10.1016/j.ejca.2014.01.018

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Article

Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes.

European journal of cancer (Oxford, England : 1990) - 1 May 2014

Yang Ching-Yao, Lin Mong-Wei, Chang Yih-Leong, Wu Chen-Tu, Yang Pan-Chyr

Abstract excerpt

BACKGROUND: Programmed cell death-ligand 1 (PD-L1) is expressed in a group of cancers that may be suitable targets for specific immunotherapy. This study investigated the expression of PD-L1 in surgically resected stage I adenocarcinomas and correlated this with known major driver mutations and clinical outcomes. MATERIALS AND METHODS: One hundred and sixty-three patients with surgically resected stage I...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Anaplastic Lymphoma Kinase
B7-H1 Antigen
Carcinoma, Non-Small-Cell Lung
ErbB Receptors
Female
Humans
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Multivariate Analysis

Mutation

Proto-Oncogene Proteins

Receptor Protein-Tyrosine Kinases

Survival Analysis

Source

Open in PubMed

Identifiers

PMID: 24548766
DOI: 10.1016/j.ejca.2014.01.018

Genes

ALK
BRAF
EGFR
KRAS

Provenance

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