Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Tmod cellular logic gate as a solution for tumor-selective immunotherapy

11 May 2022

Abstract excerpt

Immune cells that are engineered with receptors to integrate signals from multiple antigens offer a promising route to achieve the elusive property of therapeutic selectivity in cancer patients. Several types of multi-signal integrators have been described, among them mechanisms that pair activating and inhibitory receptors which are termed NOT gates by analogy to logical operations performed by machines. Here we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35561999
DOI: 10.1016/j.clim.2022.109030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Tmod cellular logic gate as a solution for tumor-selective immunotherapyPMID 35561999Read ↗

Targeting loss of heterozygosity for cancer-specific immunotherapy.Semantic proximity Read ↗

Single-cell-guided identification of logic-gated antigen combinations for designing effective and safe CAR therapySemantic proximity Read ↗

Cancer T-cell therapy: building the foundation for a cureSemantic proximity Read ↗

Engineering T Cells to Treat Cancer: The Convergence of Immuno-Oncology and Synthetic BiologySemantic proximity Read ↗

Exploring the rules of chimeric antigen receptor phenotypic output using combinatorial signaling motif libraries and machine learningSemantic proximity Read ↗

Single-cell mapping of combinatorial target antigens for CAR switches using logic gatesSemantic proximity Read ↗

Decoding CAR T cell phenotype using combinatorial signaling motif libraries and machine learning.Semantic proximity Read ↗

Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairsSemantic proximity Read ↗

Rewiring Cancer Drivers to Activate ApoptosisSemantic proximity Read ↗

T cell circuits that sense antigen density with an ultrasensitive thresholdSemantic proximity Read ↗

Engineered T cells directed at tumors with defined allelic loss.Semantic proximity Read ↗

Design of novel synthetic promoters to tune gene expression in T cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.