Article
TopHap: rapid inference of key phylogenetic structures from common haplotypes in large genome collections with limited diversity.
Bioinformatics (Oxford, England) - 13 May 2022
Caraballo-Ortiz Marcos A, Miura Sayaka, Sanderford Maxwell, Dolker Tenzin, Tao Qiqing, Weaver Steven, Pond Sergei L K, Kumar Sudhir
Abstract excerpt
MOTIVATION: Building reliable phylogenies from very large collections of sequences with a limited number of phylogenetically informative sites is challenging because sequencing errors and recurrent/backward mutations interfere with the phylogenetic signal, confounding true evolutionary relationships. Massive global efforts of sequencing genomes and reconstructing the phylogeny of severe acute respiratory syndrome...
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