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Article

An exploration in pitfalls in interpreting SDHB immunohistochemistry.

Histopathology - 1 Aug 2022

Ding Chien-Kuang Cornelia, Chan Salina, Mak Julie, Umetsu Sarah E, Simko Jeffry P, Ruiz-Cordero Roberto, Saunders Tara, Chan Emily

Abstract excerpt

AIMS: Mutations and epimutations in genes encoding the succinate dehydrogenase complex (SDHx) are associated with multiple tumour types in which identification of SDH-deficiency has significant management implications. Immunohistochemistry (IHC) for the succinate dehydrogenase B (SDHB) subunit can help to detect SDH-deficiency, which manifests as complete loss of staining in tumour cells. However, a subset of...

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PMID: 35546442
DOI: 10.1111/his.14681

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