Article
Role of WNT10A in failure of tooth development in humans and zebrafish.
Molecular genetics & genomic medicine - 1 Nov 2017
Yuan Qiuping, Zhao Min, Tandon Bhavna, Maili Lorena, Liu Xiaoming, Zhang Anqi, Baugh Evan H, Tran Tam, Silva Renato M, Hecht Jacqueline T, Swindell Eric C, Wagner Daniel S, Letra Ariadne
Abstract excerpt
BACKGROUND: Oligodontia is a severe form of tooth agenesis characterized by the absence of six or more permanent teeth. Oligodontia has complex etiology and variations in numerous genes have been suggested as causal for the condition. METHODS: We applied whole-exome sequencing (WES) to identify the cause of oligodontia in a 9-year-old girl missing 11 permanent teeth. Protein modeling and functional analysis in...
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