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Article

Use of Cabozantinib to Treat MET -amplified Pediatric Colorectal Cancer.

Journal of pediatric hematology/oncology - 1 Apr 2023

Fukui Sadahiro, Umeda Katsutsugu, Kubota Hirohito, Iwai Atsushi, Akazawa Ryo, Isobe Kiyotaka, Tanaka Kuniaki, Kouzuki Kagehiro, Kawabata Naoko, Saida Satoshi, Kato Itaru, Hiramatsu Hidefumi, Itatani Yoshiro, Funakoshi Taro, Adachi Souichi, Takita Junko

Abstract excerpt

Pediatric colorectal cancer (CRC) is extremely rare, with little information about genetic profiles compared with adult CRC. Here, a 13-year-old male with advanced CRC underwent cancer gene panel testing, which detected 4 genetic abnormalities ( MET amplification in addition to TP53 , SMAD4 , and CTNNA1 mutations) that might be associated with a poor prognosis. Based on high-level MET amplification, he received a...

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Identifiers

PMID: 35536994
DOI: 10.1097/MPH.0000000000002482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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