TCP1 promotes the progression of malignant tumors by stabilizing c-Myc through the AKT/GSK-3β and ERK signaling pathways

Abstract excerpt

<title>Abstract</title> <p>TCP1, one of the subunits of molecular chaperone containing tailless complex polypeptide 1 (CCT) (CCT1), maybe play an essential role in cell proliferation and tumorigenesis. However, the biological functions and the underlying mechanisms of TCP1 in tumors are not fully understood. Here, we found that TCP1 levels increased with successive generations of xenografted tumors and were assoc...

Topics

Open a Topic to create a Post that cites this publication.

• Bioinformatics and Genomic Networks
• Cancer, Lipids, and Metabolism
• Cancer, Stress, Anesthesia, and Immune Response
• Endoplasmic Reticulum Stress and Disease
• Ferroptosis and cancer prognosis
• Heat shock proteins research
• Protein Tyrosine Phosphatases
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

9a440e20-1ce1-527b-afb9-2480fe33c8d9

DOI

10.21203/rs.3.rs-1742161/v1