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Article

CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk.

Nature genetics - 1 May 2022

Baer Constance, Kimura Shunsuke, Rana Mitra S, Kleist Andrew B, Flerlage Tim, Feith David J, Chockley Peter, Walter Wencke, Meggendorfer Manja, Olson Thomas L, Cheon HeeJin, Olson Kristine C, Ratan Aakrosh, Mueller Martha-Lena, Foran James M, Janke Laura J, Qu Chunxu, Porter Shaina N, Pruett-Miller Shondra M, Kalathur Ravi C, Haferlach Claudia, Kern Wolfgang, Paietta Elisabeth, Thomas Paul G, Babu M Madan, Loughran Thomas P, Iacobucci Ilaria, Haferlach Torsten, Mullighan Charles G

Abstract excerpt

Chronic lymphoproliferative disorder of natural killer cells (CLPD-NK) is characterized by clonal expansion of natural killer (NK) cells where the underlying genetic mechanisms are incompletely understood. In the present study, we report somatic mutations in the chemokine gene CCL22 as the hallmark of a distinct subset of CLPD-NK. CCL22 mutations were enriched at highly conserved residues, mutually exclusive of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35513723
DOI: 10.1038/s41588-022-01059-2
PMCID: PMC9117519

Genes

CCL22
CCR4
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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