Article
Complex functional redundancy of Tbx2 and Tbx3 in mouse limb development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2022
Lopatka Alika, Moon Anne M
Abstract excerpt
The limb phenotypes of Tbx2 and Tbx3 mutants are distinct: loss of Tbx2 results in isolated duplication of digit 4 in the hindlimb while loss of Tbx3 results in anterior polydactyly and posterior oligodactly in the forelimb. In the face of such disparate phenotypes, we sought to determine whether Tbx2 and Tbx3 have functional redundancy during development of the mouse limb. We found that sequential loss of...
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