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Article

Altered EZH2 splicing and expression is associated with impaired histone H3 lysine 27 tri-Methylation in myelodysplastic syndrome.

Leukemia research - 1 Dec 2017

Shirahata-Adachi Mizuho, Iriyama Chisako, Tomita Akihiro, Suzuki Yasuhiro, Shimada Kazuyuki, Kiyoi Hitoshi

Abstract excerpt

BACKGROUND: EZH2 (enhancer of zeste homolog 2) is a histone H3K27 methyltransferase involved in the pathogenesis of various hematological malignancies. In myelodysplastic syndromes (MDS), loss of function of EZH2 is known to contribute to pathogenesis, however the pattern of EZH2 mRNA and protein expression in MDS has not been extensively characterized. MATERIAL AND METHODS: A total of 26 patients diagnosed with...

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Identifiers

PMID: 29127861
DOI: 10.1016/j.leukres.2017.10.015

Genes

SET
SRSF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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