Altered EZH2 splicing and expression is associated with impaired histone H3 lysine 27 tri-Methylation in myelodysplastic syndrome.

doi:10.1016/j.leukres.2017.10.015

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Article

Altered EZH2 splicing and expression is associated with impaired histone H3 lysine 27 tri-Methylation in myelodysplastic syndrome.

Leukemia research - 1 Dec 2017

Shirahata-Adachi Mizuho, Iriyama Chisako, Tomita Akihiro, Suzuki Yasuhiro, Shimada Kazuyuki, Kiyoi Hitoshi

Abstract excerpt

BACKGROUND: EZH2 (enhancer of zeste homolog 2) is a histone H3K27 methyltransferase involved in the pathogenesis of various hematological malignancies. In myelodysplastic syndromes (MDS), loss of function of EZH2 is known to contribute to pathogenesis, however the pattern of EZH2 mRNA and protein...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Alternative Splicing
Biomarkers, Tumor
DNA Methylation
Enhancer of Zeste Homolog 2 Protein
Epigenesis, Genetic
Female
Follow-Up Studies
Histones
Humans
Lysine
Male
Middle Aged
Mutation
Myelodysplastic Syndromes

Source

Open in PubMed

Identifiers

PMID: 29127861
DOI: 10.1016/j.leukres.2017.10.015

Genes

SET
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-29127861-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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