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Article

A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility.

Genes and immunity - 1 Jul 2011

Bush W S, McCauley J L, DeJager P L, Dudek S M, Hafler D A, Gibson R A, Matthews P M, Kappos L, Naegelin Y, Polman C H, Hauser S L, Oksenberg J, Haines J L, Ritchie M D

Abstract excerpt

Gene-gene interactions are proposed as an important component of the genetic architecture of complex diseases, and are just beginning to be evaluated in the context of genome-wide association studies (GWAS). In addition to detecting epistasis, a benefit to interaction analysis is that it also inc...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21346779
DOI: 10.1038/gene.2011.3
PMCID: PMC3136581

Genes

ACTN1
CHRM3
MYH9
MYLK
SCIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21346779-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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