Article
Effect of Genetic Polymorphism Including NUP153 and SVEP1 on the Pharmacokinetics and Pharmacodynamics of Ticagrelor in Healthy Chinese Subjects.
Clinical drug investigation - 1 May 2022
Xiang Qian, Liu Zhiyan, Mu Guangyan, Xie Qiufen, Zhang Hanxu, Zhou Shuang, Wang Zining, Guo Ninghong, Huang Jie, Jiang Jie, Li Jian, Yang Guoping, Cui Yimin
Abstract excerpt
BACKGROUND AND OBJECTIVE: The search for potential gene loci that affect the pharmacodynamics and pharmacokinetics of ticagrelor is a matter of broad clinical interest. The objective of this study was to investigate the effect of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of ticagrelor in healthy Chinese subjects. METHODS: This is a multi-center study in China, including three hospitals...
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