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Article

Effect of genetic variations on ticagrelor plasma levels and clinical outcomes.

European heart journal - 1 Aug 2015

Varenhorst Christoph, Eriksson Niclas, Johansson Åsa, Barratt Bryan J, Hagström Emil, Åkerblom Axel, Syvänen Ann-Christine, Becker Richard C, James Stefan K, Katus Hugo A, Husted Steen, Steg Ph Gabriel, Siegbahn Agneta, Voora Deepak, Teng Renli, Storey Robert F, Wallentin Lars

Abstract excerpt

AIMS: Ticagrelor, a direct-acting P2Y12-receptor antagonist, is rapidly absorbed and partly metabolized to the major metabolite AR-C124910XX (ARC). To identify single-nucleotide polymorphisms (SNPs) associated with pharmacokinetics of ticagrelor and clinical outcomes, we performed a genome-wide association study (GWAS) in patients treated with ticagrelor in the PLATO trial. METHODS AND RESULTS: A two-stage design...

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Acute Coronary Syndrome
Adenosine
Cytochrome P-450 CYP3A
Glucuronosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver-Specific Organic Anion Transporter 1

Organic Anion Transporters

Purinergic P2Y Receptor Antagonists

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PMID: 25935875
DOI: 10.1093/eurheartj/ehv116

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ARC

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