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Pharmacokinetics of Eltrombopag in Healthy Chinese Subjects and Effect of Sex and Genetic Polymorphism on its Pharmacokinetic and Pharmacodynamic Variability.

European journal of drug metabolism and pharmacokinetics - 1 May 2021

Chen Jinliang, Xu Yichao, Lou Honggang, Jiang Bo, Shao Rong, Yang Dandan, Hu Yin, Ruan Zourong

Abstract excerpt

BACKGROUND AND OBJECTIVE: Eltrombopag is the first oral, small-molecule, non-peptide thrombopoietin receptor agonist for the treatment of idiopathic thrombocytopenic purpura. This study investigated the pharmacokinetics of eltrombopag in healthy Chinese subjects and evaluated the effect of sex and genetic polymorphisms on its variability. METHODS: Forty-eight healthy subjects were administered a single dose of...

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Chromatography, Liquid
Cytochrome P-450 CYP1A2
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Tandem Mass Spectrometry

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PMID: 33779967
DOI: 10.1007/s13318-021-00682-4

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