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Primary endocrine resistance of ER+ breast cancer with ESR1 mutations interrogated by droplet digital PCR

2 May 2022

Abstract excerpt

We investigated the patterns of recurrence and primary endocrine resistance according to estrogen receptor (ER) alpha gene (ESR1) mutations, as assessed by digital droplet (dd) PCR, in patients with non-metastatic ER+ breast cancer. We collected 121 formalin-fixed paraffin-embedded (FFPE) surgical specimens from ER+ breast cancer patients who had relapsed after surgery. Genomic DNA was extracted from the FFPE...

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PMID: 35501333
DOI: 10.1038/s41523-022-00424-y

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