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Article

Thoracic low grade glial neoplasm with concurrent H3 K27M and PTPN11 mutations.

Acta neuropathologica communications - 28 Apr 2022

Argenziano Michael G, Furnari Julia L, Miller Michael L, Sun Yu, Banu Matei A, Neira Justin A, Snuderl Matija, Bruce Jeffrey N, Welch Mary, McCormick Paul, Canoll Peter

Abstract excerpt

We present the case of a 41-year-old man who developed worsening mid-thoracic back pain and imaging revealed a well-circumscribed intramedullary tumor in the thoracic spinal cord. Subtotal resection was performed, and histopathological analysis showed a cytologically bland, minimally proliferative glial neoplasm. Sequencing revealed H3 K27M and an activating PTPN11 mutation. Serial imaging revealed slow tumor...

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Identifiers

PMID: 35484611
DOI: 10.1186/s40478-022-01340-9
PMCID: PMC9052613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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