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The Capacity to Repair Sperm DNA Damage in Zygotes is Enhanced by Inhibiting WIP1 Activity

5 Apr 2022

Abstract excerpt

Maintaining genome integrity in germ cells is essential not only for successful fertilization and embryo development, but also to ensure proper transmission of genetic information across generations. However, unlike oocytes, sperm are incapable of repairing DNA damage. Therefore, sperm DNA damage is repaired after fertilization in zygotes using maternal DNA repair factors. In this study, we found that zygotic...

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PMID: 35478962
DOI: 10.3389/fcell.2022.841327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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