Article
Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations.
Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2007
Marchetti F, Essers J, Kanaar R, Wyrobek A J
Abstract excerpt
Male and female germ cells can transmit genetic defects that lead to pregnancy loss, infant mortality, birth defects, and genetic diseases in offspring; however, the parental origins of transmitted defects are not random, with de novo mutations and chromosomal structural aberrations transmitted predominantly by sperm. We tested the hypotheses that paternal mutagenic exposure during late spermatogenesis can induce...
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