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Article

Molecular docking of the pentapeptide derived from rice bran protein as anticancer agent inhibiting both receptor and non-receptor tyrosine kinases.

Journal of biomolecular structure & dynamics - 1 Jul 2023

Gasymov Oktay K, Kecel-Gunduz Serda, Celik Sefa, Akyuz Sevim, Ozel Ayşen E, Agaeva Gulshen, Suleymanova Leman M, Agaeva Ulker, Bakhishova Matanat, Aliyev J A

Abstract excerpt

The cationic pentapeptide Glu-Gln-Arg-Pro-Arg (EQRPR) belongs to the family of anti-cancer peptides with significant anti-cancer activity. However, the mechanism by which the peptide performs this activity is unknown. In this study, we explored the pharmaceutical profile of Glu-Gln-Arg-Pro-Arg pentapeptide and revealed its anticancer properties by in silico docking studies. Moreover, the effect of EQRPR behavior...

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Identifiers

PMID: 35477348
DOI: 10.1080/07391102.2022.2067234

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