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Article

Identification of potential edible spices as EGFR and EGFR mutant T790M/L858R inhibitors by structure-based virtual screening and molecular dynamics.

Journal of biomolecular structure & dynamics - 1 Mar 2024

Ahmad Ansari Iqrar, Debnath Bimal, Kar Saikat, Patel Harun M, Debnath Sudhan, Zaki Magdi E A, Pal Pinaki

Abstract excerpt

Epidermal growth factor receptor (EGFR) tyrosine kinases are overexpressed in several human cancers and could serve as a promising anti-cancer drug target. With this in view, the main aim of the present study was to identify spices having the potential to inhibit EGFR tyrosine kinase. The structure-based virtual screening of spice database consisting of 1439 compounds with EGFR tyrosine kinase (PDB ID: 3W32) was...

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PMID: 37349948
DOI: 10.1080/07391102.2023.2223661

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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