Reversion mutation of cDNA CA8-204 minigene construct produces a truncated functional peptide that regulates calcium release in vitro and produces profound analgesia in vivo.

doi:10.1007/s00335-020-09848-y

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Reversion mutation of cDNA CA8-204 minigene construct produces a truncated functional peptide that regulates calcium release in vitro and produces profound analgesia in vivo.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2020

Upadhyay Udita, Zhuang Gerald Z, Diatchenko Luda, Parisien Marc, Kang Yuan, Sarantopoulos Konstantinos D, Martin Eden R, Smith Shad B, Maixner William, Levitt Roy C

Abstract excerpt

Intracellular calcium is critical in orchestrating neuronal excitability and analgesia. Carbonic anhydrase-8 (CA8) regulates intracellular calcium signaling through allosteric inhibition of neuronal inositol trisphosphate receptor 1 (ITPR1) to produce profound analgesia. Recently, we reported the "G" allele at rs6471859 represents cis-eQTL regulating alternative splicing of a 1697 bp transcript (CA8-204G) with a...

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PMID: 33247772
DOI: 10.1007/s00335-020-09848-y

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