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The non-classical major histocompatibility complex II protein SLA-DM is crucial for African swine fever virus replication

21 Aug 2023

Abstract excerpt

African swine fever virus (ASFV) is a lethal animal pathogen that enters its host cells through endocytosis. So far, host factors specifically required for ASFV replication have been barely identified. In this study a genome-wide CRISPR/Cas9 knockout screen in porcine cells indicated that the genes RFXANK, RFXAP, SLA-DMA, SLA-DMB, and CIITA are important for productive ASFV infection. The proteins encoded by...

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PMID: 37604847
DOI: 10.1038/s41598-023-36788-9

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