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Cefotaxime Exposure Selects Mutations within the CA-Domain of envZ Which Promote Antibiotic Resistance but Repress Biofilm Formation in Salmonella.

Microbiology spectrum - 29 Jun 2022

Trampari Eleftheria, Zhang Chuanzhen, Gotts Kathryn, Savva George M, Bavro Vassiliy N, Webber Mark

Abstract excerpt

Cephalosporins are important beta lactam antibiotics, but resistance can be mediated by various mechanisms including production of beta lactamase enzymes, changes in membrane permeability or active efflux. We used an evolution model to study how Salmonella adapts to subinhibitory concentrations of cefotaxime in planktonic and biofilm conditions and characterized the mechanisms underpinning this adaptation. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35475640
DOI: 10.1128/spectrum.02145-21
PMCID: PMC9241649

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