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Article

Early detection and intervention of clonal hematopoiesis for preventing hematological malignancies.

Cancer letters - 10 Jul 2022

Ye Baixin, Sheng Yuping, Zhang Mingming, Hu Yongxian, Huang He

Abstract excerpt

Clonal hematopoiesis (CH) is a clonal expansion of single hematopoietic stem cells (HSC) with germline or somatic mutations accumulated in specific genes, which usually leads to clonal dominance via multiple biological pathways and increases the risk of developing hematological malignancies. With the advancement of Next Generation Sequencing (NGS) technology, CH can be widely detected in healthy individuals, many...

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PMID: 35469959
DOI: 10.1016/j.canlet.2022.215691

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