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Nanobody-based CAR-T cells for cancer immunotherapy

25 Apr 2022

Abstract excerpt

Chimeric antigen receptor T-cell (CAR-T) therapy is the result of combining genetic engineering-based cancer immunotherapy with adoptive cell therapy (ACT). CAR-T therapy has been successful in treating various types of hematological cancers. CARs are receptors made of an extracellular domain, a membrane-spanning domain, and an intracellular domain. The extracellular domain of CARs harbors an antigen-targeting...

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PMID: 35468841
DOI: 10.1186/s40364-022-00371-7

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