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Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair

6 Apr 2022

Abstract excerpt

The vast majority of cancer patients receive DNA-damaging drugs or ionizing radiation (IR) during their course of treatment, yet the efficacy of these therapies is tempered by DNA repair and DNA damage response (DDR) pathways. Aberrations in DNA repair and the DDR are observed in many cancer subtypes and can promotede novocarcinogenesis, genomic instability, and ensuing resistance to current cancer therapy....

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PMID: 35463312
DOI: 10.3389/fonc.2022.850883

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