High-level cefiderocol and ceftazidime/avibactam resistance in KPC-producing Klebsiella pneumoniae associated with mutations in KPC and the sensor histidine kinase EnvZ

Abstract excerpt

Infections caused by carbapenem-resistant Enterobacterales (CRE), including carbapenemase-producing Klebsiella pneumoniae, are increasing globally and constitute a major public health threat.1 Within K. pneumoniae, KPC-type enzymes are among the most prevalent acquired carbapenemases globally,1 and in Italy the ST512 lineage has emerged as the dominant vehicle of KPC dissemination.2 The treatment of infections...

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