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Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

22 Apr 2022

Abstract excerpt

Virus infection modulates both host immunity and host genomic stability. Poly(ADP-ribose) polymerase 1 (PARP1) is a key nuclear sensor of DNA damage, which maintains genomic integrity, and the successful application of PARP1 inhibitors for clinical anti-cancer therapy has lasted for decades. However, precisely how PARP1 gains access to cytoplasm and regulates antiviral immunity remains unknown. Here, we report...

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PMID: 35460603
DOI: 10.1016/j.molcel.2022.03.034

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