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Article

Genetic susceptibility to patient-reported xerostomia among long-term oropharyngeal cancer survivors.

Scientific reports - 22 Apr 2022

Aggarwal Puja, Hutcheson Katherine A, Yu Robert, Wang Jian, Fuller Clifton D, Garden Adam S, Goepfert Ryan P, Rigert Jillian, Mott Frank E, Lu Charles, Lai Stephen Y, Gunn G Brandon, Chambers Mark S, Li Guojun, Wu Chih-Chieh, Hanna Ehab Y, Sturgis Erich M, Shete Sanjay

Abstract excerpt

Genetic susceptibility for xerostomia, a common sequela of radiotherapy and chemoradiotherapy for head and neck cancer, is unknown. Therefore, to identify genetic variants associated with moderate to severe xerostomia, we conducted a GWAS of 359 long-term oropharyngeal cancer (OPC) survivors using 579,956 autosomal SNPs. Patient-reported cancer treatment-related xerostomia was assessed using the MD Anderson...

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Cancer Survivors
Genetic Predisposition to Disease
Head and Neck Neoplasms
Microfilament Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oropharyngeal Neoplasms

Patient Reported Outcome Measures

Receptors, Cell Surface

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Identifiers

PMID: 35459784
DOI: 10.1038/s41598-022-10538-9
PMCID: PMC9033773

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