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Article

A single point mutation in the Plasmodium falciparum 3'-5' exonuclease does not alter piperaquine susceptibility.

Malaria journal - 22 Apr 2022

Boonyalai Nonlawat, Kirativanich Kirakarn, Thamnurak Chatchadaporn, Praditpol Chantida, Vesely Brian A, Wojnarski Mariusz, Griesenbeck John S, Waters Norman C

Abstract excerpt

BACKGROUND: The rise in Plasmodium falciparum resistance to dihydroartemisinin-piperaquine (DHA-PPQ) treatment has been documented in the Greater Mekong Subregion with associations with mutations in the P. falciparum chloroquine resistance transporter (pfcrt) and plasmepsin 2 (pfpm2) genes. However, it is unclear whether other genes also play a role with PPQ resistance, such as the E415G mutation in the...

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Identifiers

PMID: 35459163
DOI: 10.1186/s12936-022-04148-z
PMCID: PMC9034581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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