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Article

Expression of the Human Serotonin 5-HT7 Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a Drosophila melanogaster Glioma Model.

Cells - 9 Apr 2022

Courant Florestan, Maravat Marion, Chen Wanyin, Gosset David, Blot Lauren, Hervouet-Coste Nadège, Sarou-Kanian Vincent, Morisset-Lopez Séverine, Decoville Martine

Abstract excerpt

Gliomas are the most common primary brain tumors in adults. Significant progress has been made in recent years in identifying the molecular alterations involved in gliomas. Among them, an amplification/overexpression of the EGFR (Epidermal Growth Factor Receptor) proto-oncogene and its associated signaling pathways have been widely described. However, current treatments remain ineffective for glioblastomas, the...

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Identifiers

PMID: 35455961
DOI: 10.3390/cells11081281
PMCID: PMC9028361

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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