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Article

Genome-wide pleiotropy analysis of coronary artery disease and pneumonia identifies shared immune pathways.

Science advances - 22 Apr 2022

Yu Zhi, Zekavat Seyedeh M, Haidermota Sara, Bernardo Rachel, MacDonald Bryan T, Libby Peter, Finucane Hilary K, Natarajan Pradeep

Abstract excerpt

Coronary artery disease (CAD) remains the leading cause of death despite scientific advances. Elucidating shared CAD/pneumonia pathways may reveal novel insights regarding CAD pathways. We performed genome-wide pleiotropy analyses of CAD and pneumonia, examined the causal effects of the expression of genes near independently replicated SNPs and interacting genes with CAD and pneumonia, and tested interactions...

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Share to Coronary Artery Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genome-Wide Association Study

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Share to Polymorphism, Single Nucleotide

Share to Receptors, Interleukin-6

Source

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Identifiers

PMID: 35452290
DOI: 10.1126/sciadv.abl4602
PMCID: PMC9032941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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