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Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in lung adenocarcinoma

20 Apr 2022

Abstract excerpt

BACKGROUND: Extrachromosomal circular DNAs (eccDNAs) increase the number of proto-oncogenes by enhancing oncogene expression to promote tumorigenesis. However, there are limited reports on differential eccDNA expression and analysis in lung cancer, especially in lung adenocarcinoma (LAD). METHODS: Three LAD and three corresponding NT tissues samples were used for eccDNA next-generation sequencing analysis, and an...

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PMID: 35441736
DOI: 10.1002/jcla.24425

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