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Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures

19 Apr 2022

Abstract excerpt

Tertiary lymphoid structures (TLS) are lymph node-like immune cell clusters that emerge during chronic inflammation in non-lymphoid organs like the kidney, but their origin remains not well understood. Here we show, using conditional deletion strategies of the canonical Notch signaling mediator Rbpj, that loss of endothelial Notch signaling in adult mice induces the spontaneous formation of bona fide TLS in the...

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PMID: 35440634
DOI: 10.1038/s41467-022-29701-x

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