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UHRF1 establishes crosstalk between somatic and germ cells in male reproduction

19 Apr 2022

Abstract excerpt

Sertoli cells (SCs) support and nourish germ cells (GCs) through their crosstalk during spermatogenesis. However, the underlying epigenetic mechanism that ensures SCs' functions in this process remains unclear. Here, we report that UHRF1, a critical epigenetic regulator, is mainly expressed in human and mouse pre-mature SCs, and is essential for establishing Sertoli-Germ cell crosstalk. SC-specific UHRF1 knockout...

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Share to Epigenetics and DNA Methylation
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PMID: 35440090
DOI: 10.1038/s41419-022-04837-2

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