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LncRNA HOXA11-AS promotes glioma malignant phenotypes and reduces its sensitivity to ROS via Tpl2-MEK1/2-ERK1/2 pathway.

Cell death & disease - 9 Nov 2022

Wei Cheng, Zhang Xiaoyang, Peng Dazhao, Zhang Xu, Guo Haizhen, Lu Yalin, Luo Lin, Wang Bo, Li Zesheng, He Yingjie, Du Xuezhi, Zhang Shu, Liang Hao, Li Shenghui, Wang Sheng, Han Lei, Zhang Jianning

Abstract excerpt

Our previous studies showed that dysregulation of the long noncoding RNA (lncRNA) HOXA11-AS plays an important role in the development of glioma. However, the molecular mechanism of HOXA11-AS in glioma remains largely unknown. In this study, we explore the molecular mechanisms underlying abnormal expression and biological function of HOXA11-AS for identifying novel therapeutic targets in glioma. The expression of...

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Identifiers

PMID: 36351895
DOI: 10.1038/s41419-022-05393-5
PMCID: PMC9646708

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