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Article

Analysis to determine the effect of mutations on binding to small chemical molecules.

Journal of bioinformatics and computational biology - 1 Apr 2022

Koshlan T V, Kulikov K G

Abstract excerpt

In this paper, the authors present and describe, in detail, an original software-implemented numerical methodology used to determine the effect of mutations on binding to small chemical molecules, on the example of gefitinib, AMPPNP, CO-1686, ASP8273, erlotinib binding with EGFR protein, and imatinib binding with PPARgamma. Furthermore, the developed numerical approach makes it possible to determine the stability...

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Identifiers

PMID: 35430948
DOI: 10.1142/S0219720022400030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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